• Tylvalosin is a macrolide antibiotic. Macrolides are metabolites or derivatives of metabolites of soil organisms obtained by fermentation. They interfere with protein synthesis by reversibly binding to the 50S ribosome subunit. They are generally considered bacteriostatic.
• Tylvalosin has activity against pathogenic organisms isolated from a range of animal species – mainly Gram-positive organisms and mycoplasma but also some Gram-negative organisms. Macrolides (including tylvalosin) have been shown to have effects on the innate immune system, which may augment the direct effects of the antibiotic on the pathogen and aid the clinical situation.

• Tylvalosin has activity against the following mycoplasma species found in chickens: Mycoplasma gallisepticum.
• The minimal inhibitory concentration (MIC) of tylvalosin for M. gallisepticum ranges from 0.007 to 0.25 µg/ml.

• Tylvalosin has activity against Ornithobacterium rhinotracheale, a Gram-negative organism found in turkeys.
• The MIC of tylvalosin for Ornithobacterium rhinotracheale ranges from 0.016 to 32 µg/ml.

• Broiler chickens: Treatment of Chronic respiratory disease, Infectious sinusitis cause by Mycoplasma gallisepticum.
• Turkeys: Treatment of respiratory disease cause by Ornithobacterium rhinotracheale.

Broiler chickens and Turkeys.

• Route: Orally via drinking water

• Broiler chickens: 294 mg per liter of drinking water per day for 3 consecutive days.
• Turkeys: 294 mg per liter of drinking water per day for 5 consecutive days.

• The product should be added to a volume of water that the chickens will consume in one day.
• No other source of drinking water should be available during the medication period.