Each 1 Kg Contains.

• Sulphadiazine sodium 639.93 gm (Equi. to 625 gm sulphadiazine base)
• Trimethoprim 125 gm

• Sulphadiazine is the most active sulphonamide against gram +ve (staphylococci and streptococci) and a wide range of gram -ve organisms (Pasteurella, Proteus and pseudomonas.)
• Sulphadiazine is rapidly absorbed and execrated.
• sulphadiazine is similar in structure to PABA
• PABA is converted in the bacterial and protozoal cell into Folic acid which essential growth Factor.
• sulphadiazine act by competitive antagonism with PABA, in the bacterial cell so prevent Folic acid Formation.
• sulphadiazine is a bacteriostatic agent.
• Trimethoprim is a bactericidal antibacterial agent
• Trimethoprim act by preventing folic acid formation by blocks the conversion of dihydro folic Acid to tetrahydro folic acid by inhibiting dihydrofolate reductase.
• The combination of sulphadiazine and Trimethoprim are bactericidal broad spectrum compound.
• There is a great synergism between sulphadiazine and Trimethoprim.

• Piotrim is abroad spectrum bactericidal drug affect on gram +ve, gram-ve and Some Eimeria species.
• The potential Compound used to treat
• Avian CRD, E-coli and Salmonella spp.
• Treat fowl cholera and coryza.
• Treat some Eimeria spp. (Tenella & Necatrix)
• The great synergism between sulphadiazine and Trimethoprim give Piotrim very high efficacy.

• 1 gm / 50 kg body weight daily for 7 days.

• 500 g